1-Adamantaneacetyl chloride → HCID 49872728, compound

Participants

Reaction Steps

3-Amino-6-bromo-quinazolin-4(3H)-one and 1-adamantaneacetyl chloride were reacted as described in Example 5 to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.60-1.70 (m, 12H), 1.93-1.98 (m, 3H), 2.10 (s, 2H), 7.71 (d, J=8.7 Hz, 1H), 8.05 (dd, J=8.7, 2.4 Hz, 1H), 8.27 (s, 1H), 8.29 (d, J=2.4 Hz, 1H), 11.21 (s, 1H); MS (DCI/NH3) m/z 416 (M+H)+; Elemental Analysis: Calculated for C20H22BrN3O2: C, 57.70; H, 5.33; N, 10.09. Found: C, 57.63; H, 5.28; N, 10.06.

Provenance & Evidence