3-amino-2-(isopropylsulfanyl)-6-phenylthieno[2,3-d]pyrimidin-4(3H)-one → HCID 49872820, compound

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Reaction Steps

3-amino-2-(isopropylthio)-6-phenylthieno[2,3-d]pyrimidin-4(3H)-one and 1-adamantaneacetyl chloride were reacted as described in Example 5 to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.38 (t, J=6.7 Hz, 6H), 1.61-1.71 (m, 12H), 1.92-1.97 (m, 3H), 2.05-2.15 (m, 2H), 3.78-3.87 (m, 1H), 7.36-7.49 (m, 3H), 7.75-7.79 (m, 3H), 10.92 (s, 1H); MS (DCI/NH3) m/z 494 (M+H)+; Elemental Analysis: Calculated for C24H25N3O2S: C, 68.71; H, 6.01; N, 10.02. Found: C, 68.53; H, 5.65; N, 9.98.

Provenance & Evidence