反应详情

To a solution of Example 56B (8.5 g 40.4 mmol) in methanol (100 mL), aqueous NaOH (50%, 25 mL) was added. The reaction was stirred at room temperature for 24 hours. Methanol was evaporated and the mixture was extracted with ether and then acidified with 6N HCl to pH 2. The mixture was extracted with ether (2×50 mL), the organic layer was dried with magnesium sulfate, filtered, and concentrated to afford the title compound.

1. customMethanol was evaporated
2. extractionthe mixture was extracted with ether
3. extractionThe mixture was extracted with ether (2×50 mL)
4. dry with materialthe organic layer was dried with magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated