反应详情

The product from Example 56D and 3-amino-2-isopropylquinazolin-4(3H)-one (Aldrich) were processed using the method described in Example 42C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.20 (d, J=6.7 Hz, 3 H) 1.24 (d, J=6.7 Hz, 3 H) 1.43-1.59 (m, 4 H) 1.65-1.95 (m, 10 H) 1.97-2.08 (m, 1 H) 2.51-2.56 (m, 2 H) 3.02-3.14 (m, 1 H) 7.53 (t, J=6.9 Hz, 1 H) 7.67 (d, J=8.3 Hz, 1 H) 7.79-7.89 (m, 1 H) 8.11 (dd, J=7.9, 1.5 Hz, 1 H) 10.94 (s, 1 H); MS (ESI+) m/z 368 (M+H)+.