3-Amino-2-ethylquinazolin-4(3H)-one → HCID 49873011, compound

HRID 1853434Notes

Reaction equation

HRID 1853434 reaction equation
[CH:1]12[CH:9]([CH2:10][C:11](Cl)=[O:12])[CH:5]([CH2:6][CH2:7][CH2:8]1)[CH2:4][CH2:3][CH2:2]2.[NH2:14][N:15]1[C:24](=[O:25])[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]=[C:16]1[CH2:26][CH3:27]>>[CH:1]12[CH:9]([CH2:10][C:11]([NH:14][N:15]3[C:24](=[O:25])[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[N:17]=[C:16]3[CH2:26][CH3:27])=[O:12])[CH:5]([CH2:6][CH2:7][CH2:8]1)[CH2:4][CH2:3][CH2:2]2

Participants

3

Reactant 2

HCID 5772533-Amino-2-ethylquinazolin-4(3H)-oneHCID 86648158HCID 86648158, compound

Product 1

HCID 49873011HCID 49873011, compound

Procedure

The product from Example 56D and 3-amino-2-ethylquinazolin-4(3H)-one (Aldrich) were processed using the method described in Example 42C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.22 (t, J=7.5 Hz, 1 H) 1.40-1.59 (m, 4 H) 1.63-1.97 (m, 10 H) 1.99-2.09 (m, 1 H) 2.51-2.56 (m, 2 H) 2.56-2.67 (m, 1 H) 2.67-2.80 (m, 1 H) 7.53 (t, J=7.0 Hz, 1 H) 7.67 (d, J=7.8 Hz, 1 H) 7.80-7.89 (m, 1 H) 8.11 (dd, J=8.1, 1.4 Hz, 1 H) 10.95 (s, 1 H); MS (ESI+) m/z 354 (M+H)+.

Sources & evidence

ORD record
ord-a46da3954f934c51adf6846e9aa216b8
Source dataset
uspto-grants-2015_02
Patent number
US08962639B2

Reaction notes

Loading…