Methyl 5-chloropyrazine-2-carboxylate → HCID 68436940, compound

HRID 1853445Notes

Reaction equation

HRID 1853445 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8](Cl)=[CH:7][N:6]=1)=[O:4].[CH3:12][N:13]1[CH2:18][CH2:17][CH:16]([CH2:19][CH2:20][CH2:21][NH2:22])[CH2:15][CH2:14]1>CO>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([NH:22][CH2:21][CH2:20][CH2:19][CH:16]2[CH2:15][CH2:14][N:13]([CH3:12])[CH2:18][CH2:17]2)=[CH:7][N:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 406081Methyl 5-chloropyrazine-2-carboxylateHCID 234980804-Piperidinepropanamine,1-methyl-(9CI)

Product 1

HCID 68436940HCID 68436940, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 5-chloro-pyrazine-2-carboxylic acid methyl ester (1 equiv.) and 3-(1-methyl-piperidin-4-yl)-propylamine (1.1 equiv.) in MeOH (0.25 M) heated at 100° C. in a sealed tube for 4 h. The mixture was cooled to rt and concentrated to give a crude product which was purified by FCC.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-a7a72de830334c648d05701f980cba3b
Source dataset
uspto-grants-2015_02
Patent number
US08962644B2

Reaction notes

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