HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 3-Bromothiophene-2-carbonyl[4-(tert-butyldimethylsilyloxy)phenyl]carbamate → 8-(tert-Butyldimethylsilyloxy)thieno[2,3-c]quinolin-4(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 3-Bromothiophene-2-carbonyl[4-(tert-butyldimethylsilyloxy)phenyl]carbamate | HCID 86689440 | — |
| Catalyst | HCID 178418851 | HCID 178418851 | — |
| Product | 8-(tert-Butyldimethylsilyloxy)thieno[2,3-c]quinolin-4(5H)-one | HCID 67447577 | 111.6% |
Reaction Steps
Following Step 3 from General Procedure A, tert-butyl 3-bromothiophene-2-carbonyl[4-(tert-butyldimethylsilyloxy)phenyl]carbamate (1.0 g, 2.0 mmol) was reacted with bis(tri-tert-butylphosphine)palladium (50 mg, 0.098 mmol) to afford the desired product (740 mg, quant.) as a solid: ESI MS m/z 332 [C17H21NO2SSi+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962648B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-60eab21d366149db84190de6a35a27a4 |
| Source note | uspto-grants-2015_02 |