HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methylthiophene-2-carboxylic acid → N-(2-bromo-4-methoxyphenyl)-5-methyl-N-(5-methylthiophene-2-carbonyl)thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methylthiophene-2-carboxylic acid | HCID 74713 | — |
| Reactant | 2-Bromo-4-methoxyaniline | HCID 10899671 | — |
| Product | N-(2-bromo-4-methoxyphenyl)-5-methyl-N-(5-methylthiophene-2-carbonyl)thiophene-2-carboxamide | HCID 67447412 | 57% |
Reaction Steps
Following Step 1 from General Procedure A, 5-methylthiophene-2-carboxylic acid (8.5 g, 60 mmol) was reacted with 2-bromo-4-methoxyaniline (6.7 g, 30 mmol) to afford the desired product (5.0 g, 57%) as a solid: ESI MS m/z 327 [C13H12BrNO2S+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962648B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-760d19deecd247f78d6637732623cc79 |
| Source note | uspto-grants-2015_02 |