HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-bromo-4-methoxyphenyl)-5-methyl-N-(5-methylthiophene-2-carbonyl)thiophene-2-carboxamide → 8-Methoxy-2-methylthieno[2,3-c]quinolin-4(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-bromo-4-methoxyphenyl)-5-methyl-N-(5-methylthiophene-2-carbonyl)thiophene-2-carboxamide | HCID 67447412 | — |
| Catalyst | HCID 178418851 | HCID 178418851 | — |
| Product | 8-Methoxy-2-methylthieno[2,3-c]quinolin-4(5H)-one | HCID 67447573 | 481.8% |
Reaction Steps
Following Step 3 from General Procedure A, N-(2-bromo-4-methoxyphenyl)-5-methyl-N-(5-methylthiophene-2-carbonyl)thiophene-2-carboxamide (500 mg, 1.1 mmol) was reacted with bis(tri-tert-butylphosphine)palladium (45 mg, 0.089 mmol) to afford the desired product (1.3 g, 48%) as a green solid: ESI MS m/z 246 [C13H11NO2S+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962648B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-c4f8232274154e2a8a24dae87cdf7ee4 |
| Source note | uspto-grants-2015_02 |