HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-bromothiophene-2-carbonyl(2-fluoro-4-methoxyphenyl)carbamate → 6-Fluoro-8-methoxythieno[2,3-c]quinolin-4(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-bromothiophene-2-carbonyl(2-fluoro-4-methoxyphenyl)carbamate | HCID 67450251 | — |
| Catalyst | HCID 178418851 | HCID 178418851 | — |
| Product | 6-Fluoro-8-methoxythieno[2,3-c]quinolin-4(5H)-one | HCID 67447274 | 82.9% |
Reaction Steps
Following Step 3 from General Procedure A, tert-butyl 3-bromothiophene-2-carbonyl(2-fluoro-4-methoxyphenyl)carbamate (2.0 g, 4.6 mmol) was reacted with bis(tri-tert-butylphosphine)palladium (100 mg, 0.20 mmol) to afford the desired product (950 mg, 80%) as a dark brown solid: ESI MS m/z 250 [C12H8FNO2S+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962648B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-849f9b87cacf41e594efe4d49a863e59 |
| Source note | uspto-grants-2015_02 |