3-Bromothiophene-2-carboxylic acid → HCID 67448176, compound

HRID 1853657Notes

Reaction equation

HRID 1853657 reaction equation
[Br:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([OH:9])=O.[F:10][C:11]1[C:17]([F:18])=[C:16]([O:19][CH3:20])[CH:15]=[CH:14][C:12]=1[NH2:13]>>[Br:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([NH:13][C:12]1[CH:14]=[CH:15][C:16]([O:19][CH3:20])=[C:17]([F:18])[C:11]=1[F:10])=[O:9]

Participants

3

Reactant 2

HCID 27396883-Bromothiophene-2-carboxylic acidHCID 37984952,3-Difluoro-4-methoxyaniline

Product 1

HCID 67448176HCID 67448176, compoundYield 100.3%

Procedure

Following Step 1 from General Procedure A, 3-bromothiophene-2-carboxylic acid (1.3 g, 6.3 mmol) was reacted with 2,3-difluoro-4-methoxyaniline (960 mg, 7.5 mmol) to afford the desired product (2.2 g, >99%): ESI MS m/z 349 [C12H8BrF2NO2S+H]+.

Sources & evidence

ORD record
ord-6e9aa661dabc4d4a960f39a8af5ca0d4
Source dataset
uspto-grants-2015_02
Patent number
US08962648B2

Reaction notes

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