HCID 86689441, compound → HCID 67450103, compound

HRID 1853658Notes

Reaction equation

HRID 1853658 reaction equation
Br[C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([N:9]([C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([F:25])[C:18]=1[F:26])C(=O)OC(C)(C)C)=[O:8]>CC(C)([P](C(C)(C)C)([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)C(C)(C)C)C>[F:26][C:18]1[C:17]2[NH:9][C:7](=[O:8])[C:3]3[S:4][CH:5]=[CH:6][C:2]=3[C:22]=2[CH:21]=[C:20]([O:23][CH3:24])[C:19]=1[F:25]

Participants

3

Reactant 1

HCID 86689441HCID 86689441, compound

Product 1

HCID 67450103HCID 67450103, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 178418851HCID 178418851, compoundCatalyst

Procedure

Following Step 3 from General Procedure A, tert-butyl 3-bromothiophene-2-carbonyl(2,3-difluoro-4-methoxyphenyl)carbamate (1.4 g, 3.1 mmol) was reacted with bis(tri-tert-butylphosphine)palladium (80 mg, 0.15 mmol) to afford the desired product (58 mg, 65%) as a brown solid: ESI MS m/z 268 [C12H7F2NO2S+H]+.

Sources & evidence

ORD record
ord-2e9446c107c14f82809a2733a815f1da
Source dataset
uspto-grants-2015_02
Patent number
US08962648B2

Reaction notes

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