N-bromobutanimide → HCID 67450514, compound

HRID 1853659Notes

Reaction equation

HRID 1853659 reaction equation
[F:1][C:2]1[C:11]2[NH:10][C:9](=[O:12])[C:8]3[S:13][CH:14]=[CH:15][C:7]=3[C:6]=2[CH:5]=[C:4]([O:16][CH3:17])[C:3]=1[F:18].[Br:19]N1C(=O)CCC1=O>>[Br:19][C:5]1[C:6]2[C:7]3[CH:15]=[CH:14][S:13][C:8]=3[C:9](=[O:12])[NH:10][C:11]=2[C:2]([F:1])=[C:3]([F:18])[C:4]=1[O:16][CH3:17]

Participants

3

Reactant 2

HCID 67184N-bromobutanimideHCID 67450103HCID 67450103, compound

Product 1

HCID 67450514HCID 67450514, compoundYield 57%

Procedure

Following Step 4 from General Procedure A, 6,7-difluoro-8-methoxythieno[2,3-c]quinolin-4(5H)-one (300 mg, 1.1 mmol) was reacted with N-bromosuccinimide (400 mg, 2.2 mmol) to afford the desired product (200 mg, 57%) as a yellow solid: ESI MS m/z 347 [C12H6BrF2NO2S+H]+.

Sources & evidence

ORD record
ord-00c5e6c0e65f4b418c93aa38cde80bfa
Source dataset
uspto-grants-2015_02
Patent number
US08962648B2

Reaction notes

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