2-Methyl-4-methoxyaniline → HCID 55220485, compound

HRID 1853660Notes

Reaction equation

HRID 1853660 reaction equation
[Br:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([OH:9])=O.[CH3:10][C:11]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:12]=1[NH2:13]>>[Br:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([NH:13][C:12]1[CH:14]=[CH:15][C:16]([O:18][CH3:19])=[CH:17][C:11]=1[CH3:10])=[O:9]

Participants

3

Reactant 2

HCID 76102-Methyl-4-methoxyanilineHCID 27396883-Bromothiophene-2-carboxylic acid

Product 1

HCID 55220485HCID 55220485, compoundYield 80%

Procedure

Following Step 1 from General Procedure A, 3-bromothiophene-2-carboxylic acid (6.7 g, 49 mol) was reacted with 2-methyl-4-methoxyaniline (12 g, 53 mmol) to afford the desired product (13 g, 80%) as an orange solid: ESI MS m/z 331 [C12H10FNO2S+H]+.

Sources & evidence

ORD record
ord-ff408b5a8d11431f8a79bf9c43ce5cea
Source dataset
uspto-grants-2015_02
Patent number
US08962648B2

Reaction notes

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