HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-bromothiophene-2-carbonyl(4-methoxy-2-methylphenyl)carbamate → 8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-bromothiophene-2-carbonyl(4-methoxy-2-methylphenyl)carbamate | HCID 67449069 | — |
| Catalyst | HCID 178418851 | HCID 178418851 | — |
| Product | 8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-one | HCID 67450840 | 86.5% |
Reaction Steps
Following Step 3 from General Procedure A, tert-butyl 3-bromothiophene-2-carbonyl(4-methoxy-2-methylphenyl)carbamate (14 g, 33 mmol) was reacted with bis(tri-tert-butylphosphine)palladium (750 mg, 1.5 mmol) to afford the desired product (7.0 g, 85%) as a dark brown solid: ESI MS m/z 250 [C12H8FNO2S+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962648B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-f1497fac37c841a0b8f3b07a73afb29e |
| Source note | uspto-grants-2015_02 |