HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(tert-Butoxycarbonylaminomethyl)phenylboronic acid → tert-Butyl 4-(8-Methoxy-2-methyl-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)benzylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(tert-Butoxycarbonylaminomethyl)phenylboronic acid | HCID 3863163 | — |
| Reactant | 9-Bromo-8-methoxy-2-methylthieno[2,3-c]quinolin-4(5H)-one | HCID 67450116 | — |
| Product | tert-Butyl 4-(8-Methoxy-2-methyl-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)benzylcarbamate | HCID 68229071 | 57.3% |
Reaction Steps
Following General Procedure B A, 9-bromo-8-methoxy-2-methylthieno[2,3-c]quinolin-4(5H)-one (100 mg, 0.31 mmol) was reacted with 4-[(tert-butoxycarbonylamino)methyl]phenylboronic acid (120 mg, 0.40 mmol) to afford desired product (80 mg, 55%) as a brown solid: ESI MS m/z 451 [C25H26N2O4S+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962648B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-cb724ef3a3d04fcebcb36434b2939b61 |
| Source note | uspto-grants-2015_02 |