(S)-tert-Butyl (1-(4-bromophenyl)ethyl)carbamate → HCID 86689502, compound

HRID 1853811Notes

Reaction equation

HRID 1853811 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])[CH3:9])=[CH:4][CH:3]=1.Br[C:19]1[C:20]2[C:21]3[CH:35]=[CH:34][S:33][C:22]=3[C:23](=[O:32])[NH:24][C:25]=2[C:26]([CH3:31])=[CH:27][C:28]=1[O:29][CH3:30]>>[CH3:30][O:29][C:28]1[CH:27]=[C:26]([CH3:31])[C:25]2[NH:24][C:23](=[O:32])[C:22]3[S:33][CH:34]=[CH:35][C:21]=3[C:20]=2[C:19]=1[C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])[CH3:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 56973617(S)-tert-Butyl (1-(4-bromophenyl)ethyl)carbamateHCID 674500069-bromo-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-one

Product 1

HCID 86689502HCID 86689502, compoundYield 62%

Procedure

Following General Procedure E, (S)-tert-butyl 1-(4-bromophenyl)ethylcarbamate (60 mg, 0.20 mmol) was reacted with 9-bromo-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-one (60 mg, 0.20 mmol) to afford the desired product (52 mg, 62%) as a brown solid: ESI MS m/z 465 [C26H28N2O4S+H]+.

Sources & evidence

ORD record
ord-b01ea7b0d1954ab8b5a636711842f931
Source dataset
uspto-grants-2015_02
Patent number
US08962648B2

Reaction notes

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