HCID 9903744, compound → HCID 67449274, compound

HRID 1853833Notes

Reaction equation

HRID 1853833 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:14])[CH2:9][S:10]([NH2:13])(=[O:12])=[O:11])=[CH:4][CH:3]=1.Br[C:16]1[C:17]2[C:18]3[CH:32]=[CH:31][S:30][C:19]=3[C:20](=[O:29])[NH:21][C:22]=2[C:23]([CH3:28])=[CH:24][C:25]=1[O:26][CH3:27]>>[CH3:27][O:26][C:25]1[CH:24]=[C:23]([CH3:28])[C:22]2[NH:21][C:20](=[O:29])[C:19]3[S:30][CH:31]=[CH:32][C:18]=3[C:17]=2[C:16]=1[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:14])[CH2:9][S:10]([NH2:13])(=[O:12])=[O:11])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 9903744HCID 9903744, compoundHCID 674500069-bromo-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-one

Product 1

HCID 67449274HCID 67449274, compoundYield 8.4%

Procedure

Following General Procedure E, 2-(4-bromophenyl)propane-1-sulfonamide (0.12 g, 0.43 mmol) was reacted with 9-bromo-8-methoxy-6-methylthieno[2,3-c]quinolin-4(5H)-one (0.14 g, 0.44 mmol) to afford the desired product (16 mg, 8%) as a brown solid: ESI MS m/z 443 [C22H22N2O4S2+H]+.

Sources & evidence

ORD record
ord-e1b09d00b57548169b3fec099c33f16b
Source dataset
uspto-grants-2015_02
Patent number
US08962648B2

Reaction notes

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