Boron tribromide → HCID 86689545, compound

Participants

Reaction Steps

Following General Procedure F, tert-butyl 4-(6-chloro-8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)benzylcarbamate (15 mg, 0.032 mmol) was reacted with tribromoborane (1.0 M in methylene chloride, 1 mL, 1 mmol) to afford the desired product (10 mg, 80%) as a brown solid: 1H NMR (500 MHz, CD3OD) δ 7.64 (d, J=8.2 Hz, 2H), 7.59 (d, J=5.4 Hz, 1H), 7.43-7.38 (m, 2H), 7.30 (s, 1H), 6.08 (d, J=5.4 Hz, 1H), 4.27 (s, 2H); ESI MS m/z 357 [C18H13ClN2O2S+H]+; ESI MS m/z 357 [C18H13ClN2O2S+H]+; HPLC 98.4% (AUC), tR=8.62 min.

Provenance & Evidence