(S)-4-Benzyl-2-oxazolidinone → HCID 67450104, compound

HRID 1853895Notes

Reaction equation

HRID 1853895 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[C:4]([F:12])[CH:3]=1.[CH2:13]([C@H:20]1[CH2:24][O:23][C:22](=[O:25])[NH:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([C@@H:20]1[CH2:24][O:23][C:22](=[O:25])[N:21]1[C:9](=[O:11])[CH2:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][C:4]=1[F:12])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 736225(S)-4-Benzyl-2-oxazolidinoneHCID 140537922-(4-Bromo-2-fluorophenyl)acetic acid

Product 1

HCID 67450104HCID 67450104, compoundYield 36%

Procedure

Following the procedure outlined for Example 627, (2-(4-bromo-2-fluorophenyl)acetic acid) (10.8 g, 30.7 mmol) reacted with (S)-(+)-4-benzyl-2-oxazolidinone (5.44 g, 30.7 mmol) to obtain the desired product (4.5 g, 36%) as white solid. ESI MS nm/393 [C18H15BrFNO3+H]+

Sources & evidence

ORD record
ord-1c672bf76e324e8e82a8db9cc83a22f6
Source dataset
uspto-grants-2015_02
Patent number
US08962648B2

Reaction notes

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