HuagongsheHuagongshe Chemistry Print Report · For research reference only
(o-Chlorophenyl)acetonitrile → 2-(2-Chlorophenyl)propanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (o-Chlorophenyl)acetonitrile | HCID 76112 | — |
| Reactant | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| Reactant | HCID 178418629 | HCID 178418629 | — |
| Product | 2-(2-Chlorophenyl)propanenitrile | HCID 12636572 | 87% |
Reaction Steps
Following the procedure outlined for Example 649, 2-(2-chlorophenyl)acetonitrile (15 g, 98.9 mmol) was reacted with NaHMDS (118 mL, 118 mmol), and methyl iodie (7.0 mL, 108 mmol) to afford the desired product (14 g, 87%) as a brown oil: ESI MS m/z 166 [C9H8ClN+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962648B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-190d27f4aa5f420db521776bd99fa6b6 |
| Source note | uspto-grants-2015_02 |