反应详情

To a solution of 2-(2-chlorophenyl)propanenitrile (14 g, 84.8 mmol) in toluene at 0° C. was added BH3.THF (127, 255 mmol) and the reaction was warmed to room temperature and heated at reflux for 4 h. The reaction mixture was cooled; quenched with water, concentrated and the residue was purified by column chromatography (silica, ethyl acetate/hexanes gradient) to obtain the desired product (13.9 g, 97%) as a reddish oil: ESI MS m/z 170 [C9H12ClN+H]+.

1. temperatureheated
2. temperatureat reflux for 4 h
3. temperatureThe reaction mixture was cooled
4. customquenched with water
5. concentrationconcentrated
6. customthe residue was purified by column chromatography (silica, ethyl acetate/hexanes gradient)