HuagongsheHuagongshe Chemistry Print Report · For research reference only
Borane;tetrahydrofuran → 1-[1-(4-Bromophenyl)cyclopropyl]methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Borane;tetrahydrofuran | HCID 2723981 | — |
| Reactant | 1-(4-Bromophenyl)Cyclopropanecarbonitrile | HCID 2795273 | — |
| Product | 1-[1-(4-Bromophenyl)cyclopropyl]methanamine | HCID 28937846 | 94% |
Reaction Steps
Following the procedure outlined for Example 666, 1-(4-bromophenyl)cyclopropane carbonitrile (2.0 g, 9.0 mmol) was reacted with BH3.THF (1.0 M in THF, 50 mL, 50 mmol) to afford the desired product (1.9 g, 94%) as a yellow oil: ESI MS m/z 226 [C10H12BrN+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962648B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-dd0fd6b6bd85428abd2f8032c04c1d81 |
| Source note | uspto-grants-2015_02 |