4-(N-Boc-amino)piperidine → HCID 86689494, compound

HRID 1853923Notes

Reaction equation

HRID 1853923 reaction equation
Cl[CH2:2]/[CH:3]=[CH:4]\[B:5]1[O:9][C:8]([CH3:11])([CH3:10])[C:7]([CH3:13])([CH3:12])[O:6]1.[NH:14]1[CH2:19][CH2:18][CH:17]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH2:16][CH2:15]1>>[CH3:12][C:7]1([CH3:13])[C:8]([CH3:11])([CH3:10])[O:9][B:5](/[CH:4]=[CH:3]/[CH2:2][N:14]2[CH2:15][CH2:16][CH:17]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:25])([CH3:24])[CH3:26])[CH2:18][CH2:19]2)[O:6]1

Participants

3

Reactant 2

HCID 7238334-(N-Boc-amino)piperidineHCID 67451679HCID 67451679, compound

Product 1

HCID 86689494HCID 86689494, compoundYield 30%

Procedure

Following the procedure outlined for Example 488, (Z)-2-(3-chloroprop-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (210 mg, 1.1 mmol) was reacted with tert-butyl piperidin-4-ylcarbamate (640 mg, 3.2 mmol) to afford the desired product (100 mg, 30%) as a brown solid: ESI MS m/z 367 [C14H27BN2O2+H]+.

Sources & evidence

ORD record
ord-fc8a70ac22d6401bb8838ca04cc169ff
Source dataset
uspto-grants-2015_02
Patent number
US08962648B2

Reaction notes

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