Thionyl Chloride → HCID 86689574, compound

HRID 1853935Notes

Reaction equation

HRID 1853935 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.S(Cl)([Cl:19])=O>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]([C:14]([Cl:19])=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 27641305-(4-methoxyphenyl)thiophene-2-carboxylic Acid

Product 1

HCID 86689574HCID 86689574, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of 5-(4-methoxyphenyl)thiophene-2-carboxylic acid (0.60 g, 2.5 mmol) in toluene (4 mL) was added thionylchloride (560 mL, 7.7 mmol) and the reaction mixture was heated at 100° C. for 18 h. The reaction mixture was cooled to room temperature and concentrated to afford the desire product (642 mg, crude): ESI MS m/z 253 [C12H9ClO2S+H]+.

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. concentrationconcentrated
  3. customto afford the desire product (642 mg, crude)

Sources & evidence

ORD record
ord-677ca72c472642169f6dc1e6cb0b26a0
Source dataset
uspto-grants-2015_02
Patent number
US08962648B2

Reaction notes

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