反应详情

To a solution of 670 mg 1-(4-Nitro-phenyl)-1H-pyrazin-2-one in 100 mL MeOH, 8 g Raney Nickel (washed three times with MeOH) were introduced under a nitrogen atmosphere. Then 10 mL of a 7 M solution of NH3 in MeOH were added. The nitrogen atmosphere was replaced by a hydrogen atmosphere and the mixture was hydrogenated under normal pressure at RT. After 2 h the reaction mixture was filtered through a pad of celite. The solvents were removed under reduced pressure and the residue was subjected to the next reaction step without further purification.

1. customwas hydrogenated under normal pressure at RT
2. filtrationAfter 2 h the reaction mixture was filtered through a pad of celite
3. customThe solvents were removed under reduced pressure
4. customthe residue was subjected to the next reaction step without further purification