4-(Trifluoromethyl)phenylboronic acid → HCID 86718730, compound

HRID 1854182Notes

Reaction equation

HRID 1854182 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([CH:23]=[O:24])[C:8]([OH:22])=[C:9]([C:11]2[CH:16]=[CH:15][C:14](OC(F)(F)F)=[CH:13][CH:12]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].BrC1C(O)=C(C=C(C(C)(C)C)C=1)C=O.[F:39][C:40]([F:51])([F:50])C1C=CC(B(O)O)=CC=1>>[C:1]([C:5]1[CH:6]=[C:7]([CH:23]=[O:24])[C:8]([OH:22])=[C:9]([C:11]2[CH:12]=[CH:13][C:14]([C:40]([F:51])([F:50])[F:39])=[CH:15][CH:16]=2)[CH:10]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 3

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 71720963-Bromo-5-tert-butyl-2-hydroxybenzaldehyde2×HCID 867187195-(Tert-butyl)-2-hydroxy-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carbaldehyde

Product 1

HCID 86718730HCID 86718730, compound

Procedure

5-(tert-Butyl)-2-hydroxy-4′-(trifluoromethyl)-[1,1′-biphenyl]-3-carbaldehyde was prepared as a yellow oil using the procedure described in Intermediate 5 from 3-bromo-5-(tert-butyl)-2-hydroxybenzaldehyde (Intermediate 4) and 4-(trifluoromethyl)phenylboronic acid.

Sources & evidence

ORD record
ord-10b1c57cee3e4528b42c082909647b6a
Source dataset
uspto-grants-2015_02
Patent number
US08962657B2

Reaction notes

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