4-Chloro-3-fluorophenylboronic Acid → HCID 86718736, compound

HRID 1854188Notes

Reaction equation

HRID 1854188 reaction equation
C(C1C=C(C=O)C(O)=C(C2C=CC(OC(F)(F)F)=CC=2)C=1)(C)(C)C.Br[C:26]1[C:27]([OH:38])=[C:28]([CH:31]=[C:32]([C:34]([CH3:37])([CH3:36])[CH3:35])[CH:33]=1)[CH:29]=[O:30].[Cl:39][C:40]1[CH:45]=[CH:44][C:43](B(O)O)=[CH:42][C:41]=1[F:49]>>[C:34]([C:32]1[CH:31]=[C:28]([CH:29]=[O:30])[C:27]([OH:38])=[C:26]([C:43]2[CH:44]=[CH:45][C:40]([Cl:39])=[C:41]([F:49])[CH:42]=2)[CH:33]=1)([CH3:37])([CH3:36])[CH3:35]

Participants

4

Reactant 3

HCID 27786564-Chloro-3-fluorophenylboronic AcidHCID 71720963-Bromo-5-tert-butyl-2-hydroxybenzaldehyde2×HCID 867187195-(Tert-butyl)-2-hydroxy-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carbaldehyde

Product 1

HCID 86718736HCID 86718736, compound

Procedure

5-(tert-Butyl)-4′-chloro-3′-fluoro-2-hydroxy-[1,1′-biphenyl]-3-carbaldehyde was prepared as a yellow oil using the procedure described in Intermediate 5 from 3-bromo-5-(tert-butyl)-2-hydroxybenzaldehyde (Intermediate 4) and 4-chloro-3-fluorophenylboronic acid.

Sources & evidence

ORD record
ord-071cab850ef84bf4bfe544c84aa4e746
Source dataset
uspto-grants-2015_02
Patent number
US08962657B2

Reaction notes

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