HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-5-tert-butyl-2-hydroxybenzaldehyde → 5-(tert-Butyl)-4'-fluoro-2-hydroxy-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-5-tert-butyl-2-hydroxybenzaldehyde | HCID 7172096 | — |
| Reactant | 4-Fluoro-3-(trifluoromethyl)benzeneboronic acid | HCID 17750051 | — |
| Reactant | 5-(Tert-butyl)-2-hydroxy-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carbaldehyde | HCID 86718719 | — |
| Product | 5-(tert-Butyl)-4'-fluoro-2-hydroxy-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-carbaldehyde | HCID 86718739 | — |
Reaction Steps
5-(tert-Butyl)-4′-fluoro-2-hydroxy-3′-(trifluoromethyl)-[1,1′-biphenyl]-3-carbaldehyde was prepared as a yellow oil using the procedure described in Intermediate 5 from 3-bromo-5-(tert-butyl)-2-hydroxybenzaldehyde (Intermediate 4) and 4-fluoro-3-(trifluoromethyl)phenylboronic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962657B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-bd7b19119c0f46f38470f928700b09c8 |
| Source note | uspto-grants-2015_02 |