3,4-Dichlorobenzeneboronic acid → 3',4'-Dichloro-2-hydroxy[1,1'-biphenyl]-3-carbaldehyde

HRID 1854203Notes

Reaction equation

HRID 1854203 reaction equation
Br[C:2]1[CH:9]=[CH:8][CH:7]=[C:4]([CH:5]=[O:6])[C:3]=1[OH:10].[Cl:11][C:12]1[CH:13]=[C:14](B(O)O)[CH:15]=[CH:16][C:17]=1[Cl:18].Cl.C(NCC1C(O)=C(C2C=CC(Cl)=C(Cl)C=2)C=C(C2C=CC(Cl)=CC=2)C=1)(C)(C)C>>[Cl:11][C:12]1[CH:13]=[C:14]([C:2]2[CH:9]=[CH:8][CH:7]=[C:4]([CH:5]=[O:6])[C:3]=2[OH:10])[CH:15]=[CH:16][C:17]=1[Cl:18]

Participants

4

Reactant 3

HCID 27343303,4-Dichlorobenzeneboronic acidHCID 109105553-Bromo-2-hydroxybenzaldehydeHCID 86718765HCID 86718765, compound

Product 1

HCID 532205553',4'-Dichloro-2-hydroxy[1,1'-biphenyl]-3-carbaldehyde

Procedure

3′,4′-Dichloro-2-hydroxy-[1,1′-biphenyl]-3-carbaldehyde was prepared from 3-bromosalicylaldehyde and 3,4-dichlorophenylboronic acid using the same procedure described in Intermediate 5.

Sources & evidence

ORD record
ord-f54e157fc9df43938e033e213796afcc
Source dataset
uspto-grants-2015_02
Patent number
US08962657B2

Reaction notes

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