Formaldehyde → HCID 86718560, compound

Participants

Reaction Steps

To a mixture 2,4-dibromphenol (11.099 g, 44.06 mmol, 1.0 equiv) and paraformaldehyde (6.609 g, 5 equiv) in isopropanol (110 mL) was added tert-butylamine (16.112 g, 5 equiv) dropwise. The resulting reaction mixture was refluxed under nitrogen overnight. The reaction mixture was cooled to room temperature, filtered and the product rinsed with isopropanol and dried to give 6,8-dibromo-3-(tert-butyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine (12.65 g).

Provenance & Evidence