Boron tribromide → 1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-2-[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-1H-benzoimidazole-4-carboxylic acid

Participants

Reaction Steps

127 mg (0.20 mmol) 1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-2-[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-1H-benzoimidazole-4-carboxylic acid methyl ester were dissolved in 15 mL CH2Cl2. At 0° C. 1.8 mL (1.8 mmol) of a 1 M BBr3-solution were added. The reaction mixture was stirred for 24 h at room temperature. Because of incomplete conversion further 0.9 mL (0.9 mmol) of a 1 M BBr3-solution were added. After stirring for 24 h at room temperature the reaction mixture was concentrated and purified by preparative HPLC (CH3CN/H2O gradient+0.05% formic acid). 1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-2-[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-1H-benzoimidazole-4-carboxylic acid was obtained as a light brown, amorphous solid. Yield: 73 mg MS (ES+): m/e=549, chloro pattern.

Provenance & Evidence