4-Methylnicotinic acid → HCID 67068325, compound

Participants

Reaction Steps

4-Methylnicotinic acid (2.00 g, 14.6 mmol) and platinum(IV) oxide (0.30 g, 1.3 mmol) in AcOH (70 mL) were shaken under hydrogen at about 60 psi for about 3 days. The reaction was filtered through Celite® then concentrated under reduced pressure to afford 4-methylpiperidine-3-carboxylic acid acetate as an oil (2.9 g, 98%): LC/MS (Table 2, Method a) Rt=0.55 min; MS m/z: 144 (M+H)+.

Provenance & Evidence