4-(3-Chloro-4-fluorophenyl)-5-(3-cyano-4-fluorophenyl)-1,3-thiazole-2-carboxylic acid → 5-{4-(3-Chloro-4-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}-2-fluorobenzenecarbonitrile
Reaction equation
[Cl:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][c:10]([C:22](=[O:23])[N:24]3[CH2:25][NH:26][C:27](=[O:29])[CH2:28]3)[s:11][c:12]2-[c:13]2[cH:14][cH:15][c:16]([F:21])[c:17]([C:19]#[N:20])[cH:18]2)[cH:5][cH:6][cH:7]1.[Cl:30][c:31]1[cH:32][c:33](-[c:34]2[n:35][c:36]([C:38]([OH:39])=[O:40])[s:41][c:42]2-[c:43]2[cH:44][cH:45][c:46]([F:47])[c:48]([C:49]#[N:50])[cH:51]2)[cH:52][cH:53][c:54]1[F:37]>>[Cl:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][c:10]([C:22](=[O:23])[N:24]3[CH2:25][NH:26][C:27](=[O:29])[CH2:28]3)[s:11][c:12]2-[c:13]2[cH:14][cH:15][c:16]([F:21])[c:17]([C:19]#[N:20])[cH:18]2)[cH:5][cH:6][c:7]1[F:37]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-b4a4ebb59bff489597134f8b5d9dd79b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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