Sodium Hydroxide → HCID 70664976, compound

Participants

Reaction Steps

2.3 g (7.42 mmol) of 5-(2,2-Dimethyl-propionylamino)-1-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester are dissolved in 15 ml ethanol and 16 ml (16 mmol, 2.16 eq) of 1N NaOH is added and the reaction mixture stirred overnight at RT. After evaporation of the solvent the residue is taken up in a mixture of 10 ml CH2Cl2 and 10 ml 0.1N HCl, the organic phase is separated, dried over Na2SO4 and the solvent removed in vacuo to obtain 5-(2,2-Dimethyl-propionylamino)-1-phenyl-1H-pyrazole-3-carboxylic acid in a yield of 89% (1.9 g)

Provenance & Evidence