Cesium carbonate → HCID 70665331, compound

Participants

Reaction Conditions

Reaction Steps

6 g (25.9 mmol) of 5-Amino-1-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester are dissolved in 50 ml DMF, 4.65 g (25.9 mmol) 1-bromopinacolone and 16 g (49.1 mmol, 1.9 eq) of Cs2CO3 are added and the resulting mixture is heated to 100° C. for 4 hours. The reaction mixture is filtrated and the solvent removed in vacuo, the residue is subjected to preparative HPLC chromatography to obtain 2 g (23%) of the product.

Provenance & Evidence