Sodium Hydroxide → HCID 70665037, compound

Participants

Reaction Steps

2 g (6.07 mmol) of 5-(3,3-Dimethyl-2-oxo-butylamino)-1-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester are dissolved in 15 ml ethanol, 12.1 ml (12.1 mmol, 2 eq) 1N NaOH are added and the resulting mixture is stirred overnight at RT. After evaporation of the solvent the residue is taken up in a mixture of 10 ml CH2Cl2 and 10 ml 0.1N HCl, the organic phase is separated, dried over Na2SO4 and the solvent removed in vacuo to obtain 5-(3,3-Dimethyl-2-oxo-butylamino)-1-phenyl-1H-pyrazole-3-carboxylic acid in a yield of 82% (1.5 g)

Provenance & Evidence