HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → methyl 2-bromo-D-phenylalaninate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | (2R)-2-amino-3-(2-bromophenyl)propanoic acid | HCID 7023575 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | methyl 2-bromo-D-phenylalaninate hydrochloride | HCID 117720502 | 100.5% |
Reaction Steps
Dissolve 2-bromo-D-phenylalanine (22.4 g, 91.8 mmol) in methanol (459 mL). Add acetyl chloride (65.3 mL, 917.7 mmol) at room temperature. Stir for 36 hours. Concentrate under reduced pressure to give the title compound (27.2 g, 92.3 mmol). MS (m/z): 258 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962654B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-8063687b5ec2455dabf95f5caa4ac33f |
| Source note | uspto-grants-2015_02 |