Hydrochloric Acid → HCID 117720355, compound

Participants

Reaction Steps

Dissolve tert-butyl (1S,3R)-3-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-(3-hydroxy-3-methyl-butyl)-1-methyl-3,4-dihydro-1H-isoquinoline-2-carboxylate (161 mg, 0.34 mmol) in ethyl acetate (962 μL). Cool on an ice bath. Add hydrogen chloride (843 μL, 3.37 mmol, 4M in dioxane) and stir on the ice bath for 4 hours. Concentrate under reduced pressure. Dissolve in ethanol and concentrate under reduced pressure to give the title compound (100 mg, 0.34 mmol). MS (m/z): 264.2 (M+1).

Provenance & Evidence