HCID 123708140, compound → HCID 123347188, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 1-((1S,3R)-5-acetyl-3-(((tert-butyldimethylsilyl)oxy)methyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-(2,6-dichlorophenyl)ethan-1-one (68 mg, 130 μmol) in THF (1.3 mL). Cool to 0° C., add MeMgCl (87 μL, 261 μmol, 3M in Et2O). Stir 30 min at 0° C. and 30 min at room temperature. Add MeMgCl (87 μL, 261 μmol, 3M in Et2O) at rt. Stir 60 min. Add water and extract with ethyl acetate three times. Combine the ethyl acetate extracts, dry over sodium sulfate, filter, and concentrate under reduced pressure to give the title compound as a white foam (0.054 g, 100 μmol). MS (m/z): 536.2 (M+1).

Provenance & Evidence