Trifluoroacetic acid → 2-Chloro-5-(1-methylethyl)benzeneacetic acid

Participants

Reaction Steps

Dissolve tert-butyl 2-(2-chloro-5-isopropyl-phenyl)acetate (483 mg, 1.80 mmol) in dichloromethane (5.1 mL). Add trifluoroacetic acid (1.09 mL, 14.4 mmol) slowly and stir the reaction mixture 3 hours at ambient temperature. Concentrate under reduced pressure to give the title compound (380 mg, 1.79 mmol). MS (m/z): 229.8 (M+18). The following compound is prepared essentially by the method of Preparation 49.

Provenance & Evidence