HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybenzylamine → N-(4-Methoxybenzyl)-5-[6-(4-methylpyridin-2-ylamino)pyridin-2-yl]oxazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybenzylamine | HCID 75452 | — |
| Reactant | 2-Chloro-1,3-oxazole | HCID 13371074 | — |
| Reactant | 5-[6-(4-methylpyridin-2-ylamino)pyridin-2-yl]-N-(pyridin-4-ylmethyl)oxazol-2-amine | HCID 67345865 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | N-(4-Methoxybenzyl)-5-[6-(4-methylpyridin-2-ylamino)pyridin-2-yl]oxazol-2-amine | HCID 67324618 | — |
Reaction Steps
Prepared as for 5-[6-(4-methylpyridin-2-ylamino)pyridin-2-yl]-N-(pyridin-4-ylmethyl)oxazol-2-amine above from the chlorooxazole and 4-methoxybenzylamine in iPrOH. 1H NMR (300 MHz, DMSO-d6) δ 9.60 (s, 1H), 8.18-8.00 (m, 2H), 7.75 (s, 1H), 7.63 (t, J=7.9 Hz, 1H), 7.45 (d, J=8.3 Hz, 1H), 7.38-7.24 (m, 3H), 6.95-6.86 (m, 3H), 6.73 (d, J=5.0 Hz, 1H), 4.37 (d, J=5.9 Hz, 2H), 3.72 (s, 3H), 2.30 (s, 3H). (ESI+) m/z 388 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08962665B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-d5e62c63b1634d0c9d537571fdc1fb56 |
| Source note | uspto-grants-2015_02 |