Potassium Carbonate → {6-[2-(2-Methoxy-pyridin-3-yl)-oxazol-5-yl]-pyridin-2-yl}-(4-methyl-pyridin-2-yl)-amine

Participants

Reaction Steps

Prepared as for (4-methyl-pyridin-2-yl)-[6-(2-phenyl-oxazol-5-yl)-pyridin-2-yl]-amine above using [6-(2-iodo-oxazol-5-yl)-pyridin-2-yl]-(4-methyl-pyridin-2-yl)-amine, 2-methoxy-pyridine-3-boronic acid, K2CO3 and Pd(PPh3)4 in a 2:1 mixture by volume of THF and water to give {6-[2-(2-methoxy-pyridin-3-yl)-oxazol-5-yl]-pyridin-2-yl}-(4-methyl-pyridin-2-yl)-amine as a yellow solid. 1-1 NMR (400 MHz, DMSO-d6) δ 9.76 (s, 1H), 8.46-8.31 (m, 2H), 8.12 (d, J=5.0 Hz, 1H), 7.87-7.82 (m, 2H), 7.82-7.75 (m, 1H), 7.63 (d, J=8.4 Hz, 1H), 7.34 (d, J=7.3 Hz, 1H), 7.21 (dd, J=7.5, 5.0 Hz, 1H), 6.78 (d, J=5.0 Hz, 1H), 4.04 (s, 3H), 2.33 (s, 3H). (ESI+) m/z 360 (M+H)+. Retention time=2.54 mins (method 1).

Provenance & Evidence