HCID 67324535, compound → HCID 67325540, compound

Participants

Reaction Steps

By following essentially the same procedure in preparative example 019 and starting with N-(6-bromopyridin-2-yl)-4-methylpyrimidin-2-amine (215 mg 0.81 mmol) and 3-(5-(tributylstannyl)thiazol-2-yl)benzonitrile (656 mg, 1.38 mmol), the 3-(5-(6-(4-methylpyrimidin-2-ylamino)pyridin-2-yl)thiazol-2-yl)benzonitrile was obtained and purified by dry flash chromatography over SiO2 eluting with DCM/MeOH (5%)/NEt3 (0.5%), by precipitation in DCM/MeOH and by trituration with Et2O (119 mg, 39%). 1H NMR (300 MHz, DMSO-d6) δ 9.60 (br s, 1H), 8.62 (s, 1H), 8.43 (d, J=5.0 Hz, 1H), 8.38 (d, J=2.3 Hz, 1H), 8.31-8.23 (m, 2H), 8.01-7.95 (m, 1H), 7.86 (t, J=8.0 Hz, 1H), 7.75 (t, J=7.9 Hz, 1H), 7.64 (d, J=7.5 Hz, 1H), 6.89 (d, J=5.0 Hz, 1H), 2.42 (s, 3H). (APCI+) m/z 371 (M+H)+.

Provenance & Evidence