Dipropylamine → HCID 22559930, compound

Participants

Reaction Steps

To a solution of 3-formylbenzoic acid (300 mg, 2.00 mmol), N,N-diisopropylethylamine (0.70 mL, 4.0 mmol), and di-n-propylamine (0.41 mL, 3.0 mmol) in 4 mL of dry dichloromethane was added 1-ethyl-3-(3-dimethylaminopropyl)-3-ethylcarbodiimide monohydrochloride (575 mg, 3.00 mmol) at 0° C. After being stirred at room temperature overnight, the reaction mixture was diluted with diethyl ether. The solution was washed with 1N HCl, saturated NaHCO3 aqueous solution, brine, and dried over MgSO4. After filtration, the filtrate was concentrated in vacuo to obtain the title compound as a colorless oil (95 mg, 20%).

Provenance & Evidence