HCID 49806006, compound → HCID 68554607, compound

HRID 1854706Notes

Reaction equation

HRID 1854706 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10](=[O:23])[CH2:11][C:12](=[O:22])/[CH:13]=[CH:14]/[C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)=[C:4]([O:24][CH3:25])[CH:3]=1.CN(C)C1C=CC(/C=C/C(=O)CC(=O)/C=C/C2C=CC(O)=C(OC)C=2)=CC=1>>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10](=[O:23])[CH2:11][C:12](=[O:22])[CH2:13][CH2:14][C:15]2[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=2)=[C:4]([O:24][CH3:25])[CH:3]=1

Participants

3

Reactant 2

HCID 49806006HCID 49806006, compoundHCID 68548788HCID 68548788, compound

Product 1

HCID 68554607HCID 68554607, compound

Procedure

The title compound was synthesized using the same procedure employed for Example 372, but with (1E,6E)-1-(4-hydroxy-2-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione (20 mg, 59 μmol, synthesized in Example 63) as the starting material instead of (1E,6E)-1-(4-dimethylaminophenyl)-7-(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione, and was purified by silica gel column chromatography eluting with hexane/ethyl acetate=65/35 to 55/45. The product was obtained as a gum (14.4 mg, 72%) having the following characteristics.

Workup

  1. washeluting with hexane/ethyl acetate=65/35 to 55/45

Sources & evidence

ORD record
ord-1404c3ad564e4f299050dbba169dfabc
Source dataset
uspto-grants-2015_02
Patent number
US08962674B2

Reaction notes

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