HCID 49806006, compound → HCID 68550449, compound

HRID 1854711Notes

Reaction equation

HRID 1854711 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([O:26][CH3:27])=[C:6](/[CH:8]=[CH:9]/[C:10](=[O:25])[CH2:11][C:12](=[O:24])/[CH:13]=[CH:14]/[C:15]2[CH:20]=[C:19]([OH:21])[CH:18]=[CH:17][C:16]=2[O:22][CH3:23])[CH:7]=1.CN(C)C1C=CC(/C=C/C(=O)CC(=O)/C=C/C2C=CC(O)=C(OC)C=2)=CC=1>>[OH:21][C:19]1[CH:18]=[CH:17][C:16]([O:22][CH3:23])=[C:15]([CH2:14][CH2:13][C:12](=[O:24])[CH2:11][C:10](=[O:25])[CH2:9][CH2:8][C:6]2[CH:7]=[C:2]([OH:1])[CH:3]=[CH:4][C:5]=2[O:26][CH3:27])[CH:20]=1

Participants

3

Reactant 2

HCID 49806006HCID 49806006, compoundHCID 68553913HCID 68553913, compound

Product 1

HCID 68550449HCID 68550449, compound

Procedure

The title compound was synthesized using the same procedure employed for Example 372, but with (1E,6E)-1,7-bis(5-hydroxy-2-methoxyphenyl)hepta-1,6-diene-3,5-dione (19 mg, 52 μmol, synthesized in Example 255) as the starting material instead of (1E,6E)-1-(4-dimethylaminophenyl)-7-(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione, and was purified by silica gel column chromatography eluting with hexane/ethyl acetate=60/40 to 50/50. The product was obtained as a solid (14.0 mg, 73%) having the following characteristics.

Workup

  1. washeluting with hexane/ethyl acetate=60/40 to 50/50

Sources & evidence

ORD record
ord-9ef852e298b6419286b3a56203a411d9
Source dataset
uspto-grants-2015_02
Patent number
US08962674B2

Reaction notes

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