Hydrochloric Acid → HCID 90402207, compound

Participants

Reaction Steps

HCl (1 ml, 2 mmol) (2.0 M in Et2O) was added to a stirring solution of (R)—N-(1-cyclopropyl-1-(1,2,4-oxadiazol-3-yl)ethyl)-2-methylpropane-2-sulfinamide (120 mg, 0.466 mmol) in MeOH (1 ml) at rt. The reaction was allowed to stir for 1 h at rt. The reaction was then concentrated to dryness azeotroping with toluene 3× to give the expected product 1-cyclopropyl-1-(1,2,4-oxadiazol-3-yl)ethanamine hydrochloride (87 mg, 0.46 mmol, 98% yield) consistent by NMR as a white solid. 1H NMR (500 MHz, METHANOL-d4) δ 9.38 (s, 1H), 1.67 (s, 3H), 1.44 (s, 1H), 0.74-0.66 (m, 2H), 0.62-0.56 (m, 1H), 0.51-0.45 (m, 1H).

Provenance & Evidence