2-Chloro-4,6-dimethoxy-1,3,5-triazine → 3-(4,6-dimethoxy-1,3,5-triazin-2-yl)-5-fluoro-1,3-dihydro-2H-indol-2-one

HRID 1854773Notes

Reaction equation

HRID 1854773 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.Cl[C:13]1[N:18]=[C:17]([O:19][CH3:20])[N:16]=[C:15]([O:21][CH3:22])[N:14]=1>>[CH3:22][O:21][C:15]1[N:16]=[C:17]([O:19][CH3:20])[N:18]=[C:13]([CH:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=3)[NH:7][C:6]2=[O:11])[N:14]=1

Participants

3

Reactant 2

HCID 184502-Chloro-4,6-dimethoxy-1,3,5-triazineHCID 37310125-fluoro-1,3-dihydro-2H-indol-2-one

Product 1

HCID 679830043-(4,6-dimethoxy-1,3,5-triazin-2-yl)-5-fluoro-1,3-dihydro-2H-indol-2-one

Procedure

5-Fluoro-1,3-dihydro-2H-indol-2-one (10 g) and 2-chloro-4,6-dimethoxy-1,3,5-triazine (15.5 g) are reacted analogously to Example 1 Variant A. This gives the title compound as solid in an HPLC purity of 92% area (19 g, 91% of theory).

Sources & evidence

ORD record
ord-027068889bbc4ff3b0406902f181c645
Source dataset
uspto-grants-2015_02
Patent number
US08962828B2

Reaction notes

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