2-Chloro-4,6-dimethoxy-1,3,5-triazine → 3-(4,6-dimethoxy-1,3,5-triazin-2-yl)-7-methoxy-1,3-dihydro-2H-indol-2-one

HRID 1854774Notes

Reaction equation

HRID 1854774 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8]2.Cl[C:14]1[N:19]=[C:18]([O:20][CH3:21])[N:17]=[C:16]([O:22][CH3:23])[N:15]=1>>[CH3:23][O:22][C:16]1[N:17]=[C:18]([O:20][CH3:21])[N:19]=[C:14]([CH:8]2[C:7]3[C:11](=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][CH:6]=3)[NH:10][C:9]2=[O:12])[N:15]=1

Participants

3

Reactant 2

HCID 184502-Chloro-4,6-dimethoxy-1,3,5-triazineHCID 124803947-Methoxyindolin-2-one

Product 1

HCID 679824623-(4,6-dimethoxy-1,3,5-triazin-2-yl)-7-methoxy-1,3-dihydro-2H-indol-2-one

Procedure

7-Methoxy-1,3-dihydro-2H-indol-2-one (1.24 g) and 2-chloro-4,6-dimethoxy-1,3,5-triazine (1.84 g) are reacted analogously to Example 1 Variant A. This gives the title compound as solid in an HPLC purity of 87% area (1.04 g, 43% of theory).

Sources & evidence

ORD record
ord-b44f964d36224a4c84c2d683fe2b990f
Source dataset
uspto-grants-2015_02
Patent number
US08962828B2

Reaction notes

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